One of Singapore's finest colonial structures, the Art Museum is devoted to the study and preservation of contemporary art of the Southeast Asian region. It has a collection of art works of historical significance and aesthetic value. They include art works by Singapore and the region's pioneering and established artists, as well as works by younger artists. It offers exhibitions, educational programs, and publications on visual arts from the regional and international scenes that aim to stimulate and enrich their cultural experience.

One of the main attractions is the E-mage Gallery, which features interactive programs. These programs aim to introduce the art histories and contemporary art practices of the Southeast Asian region. Through the programs, users will have access to digitized images of art works from the collections in the Art Museum, important public institutions, and private collections in Southeast Asia. Other facilities include the Museum Café and Museum Shop, which offers refreshments, souvenirs, and publications on the visual arts. On the other hand, the Museum Library is open to art researchers by appointment.

The Museum's 10,000 sq. meters floor area also houses climatically controlled storage and collection spaces, conservation laboratory, administrative offices, photography studios, and a patron's club.